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Due to the complexity of BCR/ABL-independent TKI resistance, a central question is whether relapse acts through the canonical BCR/ABL CML pathways seen in dependent cases [...]

The experiments contained within this dissertation explore the behavioral, endocrine, and molecular factors involved in the relationship between thyroid hormone signaling [...]

The research to be presented in this thesis addresses the topic of information gathering, information extraction and information filtering in the area of bioinformatics. [...]

Molecular phenotypes, or subtypes, can describe cancer as distinct diseases within primary tissues-of-origin. Machine learning (ML) can be applied to this molecular taxon [...]

Acute cardiac injury with renal injury (acute cardiorenal syndrome) can induce chronic kidney disease (CKD), but mechanisms by which heart injury signals to kidney are un [...]

This work explores the structure and function of an important copper monooxygenase: peptidylglycine alpha-amidating monooxygenase. The canonical reaction mechanism of thi [...]

Black and white photograph of Christopher Mathews, Ph.D., Professor and Chairman of Oregon State Universitys Department of Biochemistry and Biophysics, and Peter von Hipp [...]