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Due to their genetic, behavioral, and physiological similarities to humans, rhesus macaques (Macacca mulatta) have long been used as a translational model in biomedical r [...]

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder. It is the sixth leading cause of death in the United States. Genome-wide association studies have [...]

This dissertation investigates the role of alpha-synuclein in DNA double-strand break repair, specifically non-homologous end joining via CRISPR/Cas9 lentiviral and next [...]

Amyotrophic Lateral Sclerosis is the most common adult onset motor neurodegenerative disease. The etiology of the disease remains obscure, and as such there is no effecti [...]

The United States population is rapidly aging. The population age 65 and older increased from 39.6 million in 2009 to 54.1 million in 2019 (a 36% increase) and is project [...]

Alzheimer s Disease (AD) is the leading cause of dementia in the United States yet the genetics behind this complex disease remains unclear. With the exception of Apolipo [...]

Someone in the United States develops Alzheimer’s disease every 68 seconds; by 2050 it will be every 33 seconds. Nationwide caregivers provide 80% of the care given in th [...]

Neuronal remodeling is a crucial step towards healthy maturation of synapses, circuits and eventually brain function. This process involves changes in neuron morphology s [...]

Astrocyte-mediated processes are important for maintaining neuronal homeostasis and proper synaptic transmission. Recent work from the Mandel lab has implicated astrocyte [...]