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1.
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Due to their genetic, behavioral, and physiological similarities to humans, rhesus macaques (Macacca mulatta) have long been used as a translational model in biomedical r [...]
2020 |
Abstract |
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2.
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Alzheimer's disease (AD) is an irreversible neurodegenerative disorder. It is the sixth leading cause of death in the United States. Genome-wide association studies have [...]
2017 |
Capstone |
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3.
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This dissertation investigates the role of alpha-synuclein in DNA double-strand break repair, specifically non-homologous end joining via CRISPR/Cas9 lentiviral and next [...]
2024-09-20 |
Dissertation |
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4.
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Amyotrophic Lateral Sclerosis is the most common adult onset motor neurodegenerative disease. The etiology of the disease remains obscure, and as such there is no effecti [...]
2017 |
Dissertation |
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5.
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The United States population is rapidly aging. The population age 65 and older increased from 39.6 million in 2009 to 54.1 million in 2019 (a 36% increase) and is project [...]
2023-09-07 |
Abstract |
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6.
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7.
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Neuronal remodeling is a crucial step towards healthy maturation of synapses, circuits and eventually brain function. This process involves changes in neuron morphology s [...]
2024 |
Abstract |
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8.
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Astrocyte-mediated processes are important for maintaining neuronal homeostasis and proper synaptic transmission. Recent work from the Mandel lab has implicated astrocyte [...]
2017 |
Thesis |
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9.
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10.
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Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neurodegeneration and cognitive impairment. The CD74-MIF [...]
2023-07-25 |
Abstract |
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