1.
Due to their genetic, behavioral, and physiological similarities to humans, rhesus macaques (Macacca mulatta) have long been used as a translational model in biomedical r [...]
2020 | Abstract |
2.
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder. It is the sixth leading cause of death in the United States. Genome-wide association studies have [...]
2017 | Capstone |
3.
This dissertation investigates the role of alpha-synuclein in DNA double-strand break repair, specifically non-homologous end joining via CRISPR/Cas9 lentiviral and next [...]
2024-09-20 | Dissertation |
4.
Amyotrophic Lateral Sclerosis is the most common adult onset motor neurodegenerative disease. The etiology of the disease remains obscure, and as such there is no effecti [...]
2017 | Dissertation |
5.
The United States population is rapidly aging. The population age 65 and older increased from 39.6 million in 2009 to 54.1 million in 2019 (a 36% increase) and is project [...]
2023-09-07 | Abstract |
6.
Alzheimer s Disease (AD) is the leading cause of dementia in the United States yet the genetics behind this complex disease remains unclear. With the exception of Apolipo [...]
2012 | Thesis |
7.
Someone in the United States develops Alzheimer’s disease every 68 seconds; by 2050 it will be every 33 seconds. Nationwide caregivers provide 80% of the care given in th [...]
2014-10-01 | Dissertation |
8.
Neuronal remodeling is a crucial step towards healthy maturation of synapses, circuits and eventually brain function. This process involves changes in neuron morphology s [...]
2024 | Abstract |
9.
Astrocyte-mediated processes are important for maintaining neuronal homeostasis and proper synaptic transmission. Recent work from the Mandel lab has implicated astrocyte [...]
2017 | Thesis |
10.