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Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, d [...]

Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, d [...]

Immune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. I [...]

T-cell large granular lymphocytic leukemia (T-LGLL) is a chronic lymphoproliferative disorder of mature cytotoxic T-cells. Accurate diagnosis is challenging, requiring in [...]

This novel computational framework for the analysis of single-cell gene expression data from human tumor samples enables the identification of molecular activity associat [...]

Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset important in the early response to bacterial and viral lung pathogens. Upon activation, MAIT [...]

Effective treatments for cancer have traditionally been divided into three separate arms: surgery, chemotherapy, and radiotherapy. Recently, however, a fourth arm, known [...]