Gardenin A decreases neuroinflammation, activates antioxidant response and improves cognitive and motor function in A53T alpha synuclein overexpressing mice
Oxidative stress and neuroinflammation are widespread in the Parkinson’s disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The compound Gardenin A (GA) has been shown to activate the NRF2-regulated antioxidant pathway and inhibit the NFkB-regulated pro-inflammatory pathway in a Drosophila model of PD. Here, we evaluate the effects of GA on A53T alpha-synuclein overexpressing (A53TSyn) mice.
Details
Title
Gardenin A decreases neuroinflammation, activates antioxidant response and improves cognitive and motor function in A53T alpha synuclein overexpressing mice
Creator
Gladen Kolarsky, Noah : Oregon Health and Science University Hack, Wyatt : Oregon Health and Science University Maitra, Urmila : The University of Alabama Ciesla, Lukasz : The University of Alabama Gray, Nora : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2023
