Pregnancy causes complex hormonal changes, leading to physiologic decreases of insulin sensitivity, onset of gestational diabetes (GDM), and worsening conditions associated with insulin resistance (IR). These factors, although not fully understood, are closely linked to the metabolic effects of elevated hormones during pregnancy. Studies suggest GDM can cause offspring to develop impaired glucose tolerance. Metformin reduces hepatic glucose production, increases hepatic insulin sensitivity, and combats GDM/IR conditions. It is unknown how metformin exposure during fetal development impacts glucose homeostasis in offspring.
Details
Title
Effects of diet changes and maternal metformin consumption during pregnancy on both maternal and offspring insulin resistance
Creator
Maior-Leichtfried, Anna : Oregon Health and Science University Blomenkamp, Hannah : Oregon Health and Science University Dean, Tyler : Oregon Health and Science University Kirigiti, Melissa : Oregon Health and Science University Sauter, Kristin : Oregon Health and Science University Kievit, Paul : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2024