Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia
Jenkins, Chelsea
2017

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Abstract

This dissertation presents novel evidence that PTPN11 is activated by an upstream kinase, TNK2. PTPN11-mutant JMML and AML primary patient cells have displayed significant sensitivity to TNK2 inhibition by dasatinib. My research has revealed that PTPN11 and TNK2 interact directly, allowing for TNK2 dependent phosphorylation of PTPN11.

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Title Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia
Creator Jenkins, Chelsea
Publisher Oregon Health and Science University
Date 2017
Subjects
Keywords
DOI https://doi.org/10.6083/m4wd404b
Content Type Dissertation
Degree Type Ph.D.
Department Department of Cell, Developmental and Cancer Biology
School School of Medicine
Copyright Status
Record ID 7676
Record Created 2023-06-29
Record Appears in Organizations > Departments and Divisions > School of Medicine Basic Sciences Departments > Department of Cell, Developmental and Cancer Biology
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
OHSU Works > Student Work > Dissertations
Theses and Dissertations
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