Hypoxic ischemic encephalopathy (HIE) occurs in ~4 per 1000 live term births. Infants that receive current treatments may still develop adverse neurologic outcomes. Maternal gestational creatine supplementation has been proposed as a potential prophylactic neuroprotective therapy, with evidence of reduction in perinatal brain injury in rodent and sheep studies. The current study aims to characterize aspects of creatine synthesis, metabolism, and transport in gestational and neonatal tissues following maternal oral creatine supplementation.
Details
Title
Maternal and perinatal outcomes of maternal creatine supplementation as a therapy for neonatal encephalopathy
Creator
Dimagiba, Yvonne T. : Oregon Health and Science University Tripathy, Sudeshna : Oregon Health and Science University Ellery, Stacey J. : Hudson Medical Research Institute Snow, Rod J. : Deakin University Walker, David W. : RMIT University Sherman, Larry S. : Oregon Health and Science University Kelleher, Meredith A. : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2022
