Bioinformatics & Computational Biomedicine

Patient stratification is essential for addressing breast cancer's inter- and intra-heterogeneity. While the PAM50 classifier is widely regarded to be the gold standard f [...]

Here we evaluated the accuracy of several freely available software packages to correct for variable gene copy numbers in microbiome profiling using the 16S rRNA gene. We [...]

The work presented in this dissertation focuses on the development of robust deep learning models to predict in-vitro cancer drug responses, with utility in precision onc [...]

This novel computational framework for the analysis of single-cell gene expression data from human tumor samples enables the identification of molecular activity associat [...]

Nearly one in five children (17%) aged 2-8 were diagnosed with either a mental, emotional, developmental, or behavioral disorder in 2016 in the US. Early identification o [...]

The goal of this scoping review using PRISMAScr guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews) is to evalua [...]

The field of microbiome research has grown exponentially over the past decade, marked by substantial investments in resources and recognition of its potential clinical si [...]

There is growing appreciation for the role that commensal microorganisms play in affecting host health and disease, especially in humans. Comprised of bacteria, fungi, vi [...]

Despite decades of conventional chemotherapy, the prognosis for patients with acute myeloid leukemia (AML) remains dismal, with 75% of patients succumbing to their diseas [...]

Contributing to proteomic diversity, alternative splicing of pre-mRNA is widespread in the human transcriptome and can greatly influence regulation of both normal and dis [...]