This dissertation investigates why remyelination becomes inefficient with age in multiple sclerosis (MS) and how this failure drives neuronal loss. Key findings include a [...]

Clathrin mediated endocytosis (CME) is emerging as a critical player in the development and progression of AD in multiple brain cell types. CME is an important intersecti [...]

During development, specific combinations of molecular cues guide the proper formation of neural circuits. Neuronal migration, axon guidance, and synapse [...]

TMEM63B is a newly identified mechanosensor that is found in many dorsal root ganglion neurons. Dorsal root ganglion neurons are responsible somatosensation and one aspec [...]

Oligodendrocytes, the myelinating glia of the central nervous system, possess P/Q-type voltage-gated calcium channels, but their function has not previously been characte [...]

Myelination depends on oligodendrocyte lineage cells (OLCs) accurately sensing and responding to physical cues within the central nervous system. This work identifies the [...]

Myelination in the CNS is essential for neuronal function, and oligodendrocytes achieve this by wrapping axons with multilayered myelin sheaths. We identify FBXW7 as a ke [...]