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Bone defects may occur after trauma, infection, or oncologic resection. Autologous bone grafting is the current treatment option; however, grafting is limited in the case [...]

The extracellular matrix (ECM) plays a governing role in regulating functional cell and tissue behavior through biochemical and biophysical signaling. Ongoing tissue engi [...]

Ossification is a developmental process where bone is created in appositional layers through the gradual calcification of the native extracellular matrix (ECM). This evol [...]

The extracellular matrix (ECM) plays a governing role in regulating functional cell and tissue behavior through biochemical and biophysical signaling. Ongoing tissue engi [...]

Bone defects can occur after trauma, infection, or oncologic resection and autologous bone grafting is the current treatment option. However, this method has its limitati [...]

Articular cartilage has a very poor regeneration potential following injury, and former dogma held that it contains no progenitor cells. However, in recent years, articul [...]

The use of synthetic mRNA-based gene modification offers several advantages over traditional DNA based gene therapy including faster translational kinetics, transient exp [...]

Articular cartilage is the tissue at the junction of bones where it's highly organized anisotropic structure facilitates its biomechanical function during skeletal motion [...]