This dissertation investigates why remyelination becomes inefficient with age in multiple sclerosis (MS) and how this failure drives neuronal loss. Key findings include a [...]

Dendritic cells (DCs) play a crucial role in mediating immune responses to pathogens and tumors, with their development influenced by signaling from the FLT3 receptor tyr [...]

Cellular microarrays are a combination of well plate and microarray technologies that create an efficient high-throughput method to quantitate the phenotypes of cells in [...]

Oligodendrocytes are specialized central nervous glia that progress through distinct cellular stages, each with its own specific morphological features, specific proteins [...]

Gene expression profiles and mass-spectrometry analysis of a plaque have revealed genes and proteins involved in atherosclerotic plaque progression. Though differentially [...]

Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, d [...]

Ionizing radiation (IR) is frequently used in the treatment of cancer through radiation therapy. However, exposure to IR also poses a significant safety risk for nuclear [...]

Cell-cell co-occurrence patterns are critical in shaping biological and clinical phenotypes, but existing tools for analyzing single-cell RNA sequencing (scRNA-seq) data [...]

Metabolic reprogramming is a fundamental hallmark of cancer, enabling tumors to sustain rapid proliferation and evade treatment by dynamically shifting nutrient acquisiti [...]

Impulsive behavior is associated with poor health outcomes and studies suggest a heritable component to impulsivity levels. Recent research has begun to identity genomic [...]