Search 11,165 records for:

Due to the complexity of BCR/ABL-independent TKI resistance, a central question is whether relapse acts through the canonical BCR/ABL CML pathways seen in dependent cases [...]

HER2-positive breast cancer is an aggressive subtype of breast cancer with patients having significantly lower survival rates compared to other breast cancers. HER2-posit [...]

Next generation sequencing (NGS) and single-cell sequencing technologies have enabled unparalleled resolution of the cell's molecular machinery; however, gleaning accurat [...]

With the growing value of next generation sequencing (NGS) assays for the determination of minimal residual disease (MRD) in the clinic, the con?dent and sensitive detect [...]

Malignant brain tumors remain incurable and improving outcomes will require personalized treatment strategies. In personalized medicine, therapeutics are tailored to each [...]

In this oral history interview, Kent Thornburg, Ph.D,, explores his career in cardiovascular and developmental health research at OHSU. He discusses the significant influ [...]

The work presented in this dissertation focuses on the development of robust deep learning models to predict in-vitro cancer drug responses, with utility in precision onc [...]

Recent research shows that microRNAs (miRNAs) may be potential biomarkers of cancer. MiRNAs are noncoding RNA molecules that regulate gene expression in the post-transcri [...]

Genome-wide polygenic risk scores (PRS) can now predict complex genetic disease risk with nearly the same ability as tests for monogenic diseases. Despite this, there is [...]

Advancing precision medicine in the treatment of cancer is complex and requires extensive molecular profiling to identify therapeutic targets and appropriately stratify p [...]