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1.
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Cancers are complex diseases that operate at multiple biological scales - from atom to organism - and the purview of cancer systems biology is to integrate information be [...]
2021 |
Dissertation |
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2.
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Malignant brain tumors remain incurable and improving outcomes will require personalized treatment strategies. In personalized medicine, therapeutics are tailored to each [...]
2019 |
Dissertation |
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3.
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4.
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5.
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Mechanisms of immune suppression in peripheral tissues counteract protective immu-nity to prevent immunopathology and are coopted by tumors for immune evasion. Blood and [...]
2019 |
Dissertation |
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6.
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Acute myeloid leukemia, the cancer studied in this dissertation, is a malignancy that occurs within the myeloid branch of hematopoiesis. Hematopoiesis is the process by [...]
2018 |
Dissertation |
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7.
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The HER2+ subtype of breast cancer typically results from amplification of the proto-oncogene ERBB2, that causes overexpression of the mitogenic cell surface receptor kin [...]
2017 |
Dissertation |
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8.
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The breast tumor microenvironment is a complex ecosystem of epithelial, immune, endothelial, fibroblast and adipose cells. Cellular phenotypes and spatial localizations w [...]
2022 |
Thesis |
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9.
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This cancer cell-intrinsic GOT2-PPARĪ“ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment, and fosters the immune-suppressive [...]
2021 |
Dissertation |
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10.
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The inability to develop an effective anti-tumor immune response plays a key role in cancer progression. Patients with a strong anti-tumor T cell response, indicated by i [...]
2016-09-01 |
Thesis |
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