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Due to their genetic, behavioral, and physiological similarities to humans, rhesus macaques (Macacca mulatta) have long been used as a translational model in biomedical r [...]

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder. It is the sixth leading cause of death in the United States. Genome-wide association studies have [...]

Alzheimer s Disease (AD) is the leading cause of dementia in the United States yet the genetics behind this complex disease remains unclear. With the exception of Apolipo [...]

Someone in the United States develops Alzheimer’s disease every 68 seconds; by 2050 it will be every 33 seconds. Nationwide caregivers provide 80% of the care given in th [...]

Neuronal remodeling is a crucial step towards healthy maturation of synapses, circuits and eventually brain function. This process involves changes in neuron morphology s [...]

Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neurodegeneration and cognitive impairment. The CD74-MIF [...]

Clathrin mediated endocytosis (CME) is emerging as a critical player in the development and progression of AD in multiple brain cell types. CME is an important intersecti [...]

This dissertation focuses on brain aging and neurodegeneration, specifically in the context of healthy brain aging versus Alzheimer's disease (AD). To study these process [...]

Cognitive deficits are an early feature of Alzheimer’s disease (AD) and vascular dementia (VD). Brain white matter hyperintensities (WMH), identified with MRI, are though [...]