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Public omics datasets from sequencing and array-based platforms now amount to millions of samples across thousands of studies and projects. This wealth of data is difficu [...]

Due to the complexity of BCR/ABL-independent TKI resistance, a central question is whether relapse acts through the canonical BCR/ABL CML pathways seen in dependent cases [...]

Cancer is now the biggest single cause of mortality worldwide, incidence has increased by 11% in four years and cases are forecast to rise by 75% over the next 20 years [ [...]

The research to be presented in this thesis addresses the topic of information gathering, information extraction and information filtering in the area of bioinformatics. [...]

In the study of rare and undiagnosed diseases it is of critical importance to identify potential gene candidates for those disease in order to establish an appropriate t [...]

Enormous data collection efforts and improvements in technology have made large-scale genome-wide association studies (GWAS) a promising approach to better understanding [...]

The gut microbiome is involved in promoting or inhibiting (protecting against or contributing to the development of) many diseases, such as diabetes, inflammatory bowel d [...]

HER2-positive breast cancer is an aggressive subtype of breast cancer with patients having significantly lower survival rates compared to other breast cancers. HER2-posit [...]

Pathway research defines or refines our understanding of interactions between molecules within and between cells, primarily to identify molecular targets for disease ther [...]