Vollum Institute

The structural and functional characterization of the human bile acid ion channel in the presence and absence of calcium are discussed.

The world is full of sound—often in the form of noisy, acoustically cluttered environments—that we must make sense of. Noise vying for our attention overlaps with the sou [...]

TMEM63B is a newly identified mechanosensor that is found in many dorsal root ganglion neurons. Dorsal root ganglion neurons are responsible somatosensation and one aspec [...]

This dissertation explores the regulation and adaptation of mu-opioid receptors (MORs) within the paraventricular nucleus of the thalamus (PVT), a brain region critical f [...]

When thinking of sodium channels in the nervous system the most notable are voltage gated sodium channels, but a multitude of non-voltage gated channels also contribute t [...]

Ischemic stroke is the most common type of stroke, accounting for about 87% of all stroke cases. Stroke is a leading cause of long-term disability and the second leading [...]

Heterozygous de novo variants in the TBR1 cause a rare form of autism called TBR1 Syndrome, which involces intellectual disability, behavioral disturbances, and speech an [...]

Understanding the molecular and genetic identity of neuron types is prerequisite to tractable control and investigation of the behavioral relevance of discrete neuronal t [...]

This dissertation combines a series of experiments using both zebrafish and mice to further our understanding of Schwann cell biology. I add to our limited understanding [...]

During neural development cells must migrate to the appropriate destination and establish connections with the appropriate cell types. The cell adhesion molecule Dystrogl [...]